The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain
Morris, Peter J. and Theil, Thomas and Ring, Christopher J. and Lillycrop, Karen A. and Moroy, Tarik and Latchman, David S. (1994) The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Molecular and Cellular Biology, 14 (10). pp. 6907-6914. ISSN 0270-7306
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The Brn-3a, Brn-3b, and Brn-3c POU family transcription factors are closely related to one another and are members of the group IV subfamily of POU factors. Here we show that despite this close relationship, the factors have different effects on the activity of a target promoter: Brn-3a and Brn-3c stimulate the promoter whereas Brn-3b represses it. Moreover, Brn-3b can antagonize the stimulatory effect of Brn-3a on promoter activity and can also inhibit promoter activation by the Oct-2.1 POU factor. The difference in the transactivation activities of Brn-3a and Brn-3b is dependent upon the C-terminal region containing the POU domain of the two proteins, since exchange of this domain between the two factors converts Brn-3a into a repressor and Brn-3b into an activator.
|Research Areas:||A. > School of Science and Technology > Natural Sciences|
|Depositing User:||Dr Christopher Ring|
|Date Deposited:||03 Dec 2009 12:23|
|Last Modified:||24 Mar 2015 13:11|
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