Zanamivir: a significant reduction in viral load during treatment in military conscripts with influenza.
Puhakka, Tuomo and Lehti, Heikki and Vainionpää, Raija and Jormanainen, Vesa and Pulkkinen, Markku and Sharp, Stephen and Kerr, Caron and Dempsey, Maria and Ring, Christopher J. and Ward, Chantelle and Tisdale, Margaret (2003) Zanamivir: a significant reduction in viral load during treatment in military conscripts with influenza. Scandinavian journal of infectious diseases, 35 (1). pp. 52-58. ISSN 0036-5548
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A randomized, double-blind, placebo-controlled, parallel-group trial performed at 5 residential units of the Finnish Defence Forces was conducted to assess the antiviral activity, efficacy and safety of inhaled zanamivir for the treatment of naturally acquired influenza. Conscripts were recruited within 2 d of onset of typical influenza symptoms and received inhaled zanamivir 10 mg via a Diskhaler twice daily for 5 d or matching placebo. Time to alleviation of clinically significant symptoms of influenza was the primary endpoint. Viral load measurements were made using quantitative real-time polymerase chain reaction assays. 435/588 patients (74%) had laboratory-confirmed influenza infection. The mean area under the curve for viral load during the first 48 h of treatment was 8.48 [95% confidence interval (95% CI) 2.85 to 14.11] log10 vRNA copies/ml x h lower in the zanamivir group compared with placebo (p = 0.003). Zanamivir reduced the time to alleviation of symptoms versus placebo in the influenza-positive group (medians 2.0 vs 2.33 d; 95% CI-0.17 to 1.0 d, p = 0.08). Zanamivir rapidly reduced viral load following the start of therapy compared with placebo and was well tolerated.
|Research Areas:||School of Science and Technology > Natural Sciences|
|Citations on ISI Web of Science:||21|
|Deposited On:||03 Dec 2009 08:54|
|Last Modified:||06 Feb 2013 11:45|
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