Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle

Neven, Patrick and Iles, Ray K. and Howes, Ian and Sharma, Kiran and Shepherd, John H. and Edwards, Ray and Collins, William P. and Chard, Tim (1993) Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle. Clinical Chemistry, 39 (9). pp. 1857-1860. ISSN 0009-9147

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Official URL: http://www.clinchem.org/cgi/content/abstract/39/9/...

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Abstract

We measured the day-to-day variations in concentrations of beta-core, luteinizing hormone (LH), and alpha-subunit in urine during the menstrual cycle. The alpha-subunit concentrations showed a pattern similar to that of the LH concentrations. beta-Core-like material was increased during and up to 3 to 4 days after the surge in urine LH. The urine LH concentration was associated with the presence of beta-core immunoreactivity during the urine LH peak. Chromatography showed that, at the peak LH concentration and at 2 days after the LH peak, beta-core immunoreactivity could be accounted for by the presence of a peptide of low molecular mass similar to the beta-core molecule of hCG, but probably originating from the degradation of LH. The prolonged excretion of gonadotropin metabolites in the midcycle must be considered when beta-core is being assessed as a tumor marker.

Item Type:Article
Research Areas:Science & Technology > Biomedical Science
Citations on ISI Web of Science:18
ID Code:2975
Deposited On:02 Nov 2009 16:17
Last Modified:23 Jan 2014 07:26

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