Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle

Neven, Patrick, Iles, Ray K., Howes, Ian, Sharma, Kiran, Shepherd, John H., Edwards, Ray, Collins, William P. and Chard, Tim (1993) Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle. Clinical Chemistry, 39 (9). pp. 1857-1860. ISSN 0009-9147

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Abstract

We measured the day-to-day variations in concentrations of beta-core, luteinizing hormone (LH), and alpha-subunit in urine during the menstrual cycle. The alpha-subunit concentrations showed a pattern similar to that of the LH concentrations. beta-Core-like material was increased during and up to 3 to 4 days after the surge in urine LH. The urine LH concentration was associated with the presence of beta-core immunoreactivity during the urine LH peak. Chromatography showed that, at the peak LH concentration and at 2 days after the LH peak, beta-core immunoreactivity could be accounted for by the presence of a peptide of low molecular mass similar to the beta-core molecule of hCG, but probably originating from the degradation of LH. The prolonged excretion of gonadotropin metabolites in the midcycle must be considered when beta-core is being assessed as a tumor marker.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
ISI Impact: 18
Item ID: 2975
Depositing User: Repository team
Date Deposited: 02 Nov 2009 16:17
Last Modified: 03 Apr 2019 17:18
URI: https://eprints.mdx.ac.uk/id/eprint/2975

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