The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines

Gillott, D. J and Iles, Ray K. and Chard, Tim (1996) The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines. British Journal of Cancer, 73 (3). pp. 323-326. ISSN 0007-0920

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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC207442...

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Abstract

The effects of human chorionic gonadotrophin (hCG) and its subunits on in vitro bladder cancer cell growth have been assessed using the a tetrazolium salt reduction assay (MTT). Intact hCG, alpha-hCG and beta-core hCG all had no effect on cell growth, while beta-hCG increased MTT reduction in all four bladder cancer lines tested. The magnitude of beta-hCG stimulation was maximal in the T24 line, which does not itself produce beta-hCG and appeared to be correspondingly lower in beta-hCG-secreting lines. The addition of antibodies to beta-hCG inhibited MTT reduction among high secretors but failed to inhibit MTT reduction in non-beta-hCG producers. These results are consistent with the poor prognosis associated with beta-hCG expression by bladder tumours in vivo and suggest an autocrine/paracrine stimulation of tumour growth by endogenously produced beta-hCG.

Item Type:Article
Research Areas:School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:70
ID Code:2969
Deposited On:02 Nov 2009 14:00
Last Modified:20 Jul 2014 05:03

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