The prognostic significance of beta human chorionic gonadotrophin and its metabolites in women with cervical carcinoma

Crawford, R. A. and Iles, Ray K. and Carter, Paul G. and Caldwell, C. J. and Shepherd, John H. and Chard, Tim (1998) The prognostic significance of beta human chorionic gonadotrophin and its metabolites in women with cervical carcinoma. Journal of Clinical Pathology, 51 (9). pp. 685-688. ISSN 0021-9746

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AIMS: To examine long term survival of women with primary and recurrent cervical carcinoma in relation to (1) excretion of beta-core (a urinary metabolite of beta human chorionic gonadotrophin (beta hCG)) and (2) beta hCG immunostaining of the tumours, to determine the suitability of these markers for assessing prognosis. METHODS: This was a prospective observational study undertaken in a gynaecological oncology centre: 57 women with primary cervical cancer and 42 with recurrent disease were recruited between January 1990 and September 1992. Kaplan-Meier survival analysis with the log rank test was used to assess survival differences with survival rate given per year of follow up. RESULTS: In primary disease, the four year survival for the beta-core negative group was 79%, compared with 14% for the beta-core positive group (p = 0.001). This was still significant for early stage disease or squamous lesions alone. In recurrent disease, beta-core positivity was not prognostically significant. Immunohistochemistry was of no prognostic significance in either group. CONCLUSIONS: beta-core excretion appears to be useful in assessing prognosis of primary cervical cancer but not of recurrent disease. A large prospective study of urinary beta-core in early stage cervical cancer is needed to determine whether it can be used as an index for modifying treatment.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
ISI Impact: 15
Item ID: 2965
Depositing User: Repository team
Date Deposited: 02 Nov 2009 12:36
Last Modified: 13 Oct 2016 14:15

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