Comparing pregnancy, childbirth, and neonatal outcomes in women with different phenotypes of polycystic ovary syndrome and healthy women: a prospective cohort study

Foroozanfard, Fatemeh, Asemi, Zatollah, Bazarganipour, Fatemeh, Taghavi, Seyed Abdolvahab, Allan, Helen T. and Aramesh, Shahintaj (2019) Comparing pregnancy, childbirth, and neonatal outcomes in women with different phenotypes of polycystic ovary syndrome and healthy women: a prospective cohort study. Gynecological Endocrinology . pp. 1-5. ISSN 0951-3590 (Published online first) (doi:10.1080/09513590.2019.1631278)

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Abstract

The aim of this study was to compare pregnancy, childbirth, and neonatal outcomes in women with different phenotypes of polycystic ovary syndrome (PCOS) with healthy women. A prospective cohort study from the beginning to the end of pregnancy for 41 pregnant women with PCOS (case) and 49 healthy pregnant women (control) was completed. Based on the presence or absence of menstrual dysfunction (M), hyperandrogenism (HA), and polycystic ovaries (PCO) on ultrasound, the PCOS (case) group were divided into three phenotypes (HA + PCO (  = 22), M + PCO (  = 9), HA + M+PCO (  = 10). Pre-eclampsia, gestational diabetes, and lower birth weight among newborns were significantly higher in the PCOS case group compared to the control group especially in the phenotype HA + M+PCO (  < .05). High BMI (  = 2.40; =.03) was the strongest predictor of pre-eclampsia in patients with PCOS. High androgen levels (free androgen index) (  = 13.71, 3.02;  < .05), was the strongest predictor of developing diabetes during pregnancy and reduced birth weight baby, respectively.These results suggest that PCOS, particularly in phenotype HA + M+PCO (  < .05), is a risk factor for adverse pregnancy and neonatal outcomes including gestational diabetes, pre-eclampsia, and reduced weight babies.

Item Type: Article
Keywords (uncontrolled): Polycystic ovary syndrome, neonatal complications, phenotype, pregnancy complications
Research Areas: A. > School of Health and Education > Adult, Child and Midwifery
Item ID: 27004
Notes on copyright: This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 02/07/2019, available online: http://www.tandfonline.com/10.1080/09513590.2019.1631278
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Depositing User: Jisc Publications Router
Date Deposited: 16 Jul 2019 08:03
Last Modified: 24 Aug 2019 00:01
URI: https://eprints.mdx.ac.uk/id/eprint/27004

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