Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads

Lu, Yongtao, Zhu, Yifan, Krause, Matthias, Huber, Gerd and Li, Junyan (2019) Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads. Medical Engineering and Physics . ISSN 1350-4533 (Published online first) (doi:https://doi.org/10.1016/j.medengphy.2019.05.007)

[img] PDF - Final accepted version (with author's formatting)
Restricted to Repository staff and depositor only until 28 May 2020.
Available under License Creative Commons Attribution-NonCommercial-NoDerivatives.

Download (1MB) |

Abstract

Prediction of the vertebral failure load is of great importance for the prevention and early treatment of bone fracture. However, an efficient and effective method for accurately predicting the failure load of vertebral bones is still lacking. The aim of the present study was to evaluate the capability of the simulated dual energy X-ray absorptiometry (DXA)-based finite element (FE) model for predicting vertebral failure loads. Thirteen dissected spinal segments (T11/T12/L1) were scanned using a HR-pQCT scanner and then were mechanically tested until failure. The subject-specific three-dimensional (3D) and two-dimensional (2D) FE models of T12 were generated from the HR-pQCT scanner and the simulated DXA images, respectively. Additionally, the areal bone mineral density (aBMD) and areal bone mineral content (aBMC) of T12 were calculated. The failure loads predicted by the simulated DXA-based 2D FE models were more moderately correlated with the experimental failure loads (R  = 0.66) than the aBMC (R  = 0.61) and aBMD (R  = 0.56). The 2D FE models were slightly outperformed by the HR-pQCT-based 3D FE models (R  = 0.71). The present study demonstrated that the simulated DXA-based 2D FE model has better capability for predicting the vertebral failure loads than the densitometric measurements but is outperformed by the 3D FE model. The 2D FE model is more suitable for clinical use due to the low radiation dose and low cost, but it remains to be validated by further in vitro and in vivo studies. [Abstract copyright: Copyright © 2019. Published by Elsevier Ltd.]

Item Type: Article
Additional Information: ** From PubMed via Jisc Publications Router ** History: received 20-11-2018; revised 11-03-2019; accepted 19-05-2019.
Keywords (uncontrolled): BMD, DXA, Finite element analysis, Prediction capability, Vertebral failure
Research Areas: A. > School of Science and Technology > Design Engineering and Mathematics
Item ID: 26797
Notes on copyright: © 2019. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Useful Links:
Depositing User: Jisc Publications Router
Date Deposited: 13 Jun 2019 08:50
Last Modified: 01 Jul 2019 19:22
URI: https://eprints.mdx.ac.uk/id/eprint/26797

Actions (login required)

Edit Item Edit Item

Full text downloads (NB count will be zero if no full text documents are attached to the record)

Downloads per month over the past year