Can quantification of Serum Glycans predict Pre-Eclampsia?

Antia, Imeobong U., Shah, Ajit J., Yagnik, Darshna, Syngelaki, Argyro, Nicolaides, K. H. and Hills, Frank (2018) Can quantification of Serum Glycans predict Pre-Eclampsia? In: International Federation of Placenta Associations Conference (IFPA2018), 21-24 Sep 2018, Jikei University School of Medicine in Tokyo, Japan.

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Objectives: To determine if concentrations of placental glycans and glycan components are altered in pre-eclamspia and to determine if serum levels can predict pre-eclampsia.

Methods: Serum samples were collected from women in the third trimester of singleton pregnancy but before the onset of pre-eclampsia and also from women during unaffected pregnancies at the samegestational age. Tissues were collected from the basal plate of placentas collected at delivery following uncomplicated singleton pregnancy (term and preterm) and from pregnancies complicated by preeclampsia. Pre-eclampsia was diagnosed according to International Society for the Study of Hypertension in Pregnancy criteria. Glycan components were isolated using a combination of enzyme digestion, molecular weight filtration and ion exchange chromatography, and then derivatised prior to separation using hydrophilic interaction liquid chromatography. Components were detected using electrospray ionisation operated in positive ion mode with single ion monitoring.

Results: Specific glycan components (designated glycan 1, 2 and 3) were significantly altered in the serum from women who went on to have preeclampsia compared to those who had an unaffected pregnancy. Interestingly, levels of the same biomarkers were also elevated in nulliparous versus multiparous pregnancy. Biomarkers were also significantly altered in placental tissues from pregnancies complicated by preeclampsia

Conclusion: This study suggests that altered glycan levels may contribute to impaired placental development and that the glycome is a potential diagnostic target for pre-eclampsia, and possibly other disorders of pregnancy.

Item Type: Conference or Workshop Item (Poster)
Additional Information: Poster abstract published in Placenta, Volume 69, September 2018, Pages e12-e93
Research Areas: A. > School of Science and Technology > Natural Sciences > Reproductive Biology group
Item ID: 26291
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Depositing User: Frank Hills
Date Deposited: 18 Mar 2019 16:12
Last Modified: 10 May 2019 17:11

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