C-myc oncoprotein expression and gene amplification in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast

Selim, Abdel-Ghani and El-Ayat, Ghada and Naase, Mahmoud and Wells, Clive A. (2002) C-myc oncoprotein expression and gene amplification in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. The Breast, 11 (6). pp. 466-472. ISSN 0960-9776

Full text is not in this repository.

Official URL: http://dx.doi.org/10.1054/brst.2002.0474

This item is available in the Library Catalogue

Abstract

Overexpression and/or amplification of c- myc oncogene are known to occur in human breast carcinomas, particularly those of high grade. Apocrine metaplasia (APM) is a common finding within fibrocystic change, and in some cases appears to be associated with an elevated risk of subsequent breast cancer. It has been suggested that apocrine metaplasia within sclerosing adenosis of the breast, also called apocrine adenosis (AA), has a premalignant potential. Little, however, is known about cellular level genetic alterations in either APM or AA of the breast. Because of this, c- myc expression and amplification in APM and AA were studied. Fluorescence in situ hybridisation (FISH) is a methodological approach to detecting these genetic alterations. In this study, APM and AA were studied immunohistochemically to detect c-myc oncoprotein expression, and FISH was employed using a DNA probe for the c- myc gene in archival tissue sections of cases of APM and AA of the breast. Nuclear immunostaining for c-myc was seen in all APM and AA cases studied, but amplification of the c- myc gene was not seen in any cases with APM or AA. The results of this study indicate that c-myc overexpression appears to occur early in breast oncogenesis. Amplification of the c- myc gene does not occur in APM or AA of the breast, however, suggesting that this particular genetic alteration constitutes a late event in the pathogenesis of breast carcinomas.

Item Type:Article
Additional Information:

PubMed PMID: 14965711.

Research Areas:School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:10
ID Code:2540
Useful Links:
Deposited On:22 Jun 2009 09:06
Last Modified:03 Feb 2014 06:56

Repository staff only: item control page

Full text downloads (NB count will be zero if no full text documents are attached to the record)

Downloads per month over the past year