CD5 mRNA expression and auto-antibody production in early human B cells immortalized by EBV

Paavonen, T. and Quartey-Papafio, R. and Delves, Peter J. and Mackenzie, L. and Lund, Torben and Youinou, P. and Lydyard, P. M. (1990) CD5 mRNA expression and auto-antibody production in early human B cells immortalized by EBV. Scandinavian Journal of Immunology, 31 (3). pp. 269-271. ISSN 0300-9475

Full text is not in this repository.

Official URL: http://www3.interscience.wiley.com/journal/1193769...

This item is available in the Library Catalogue

Abstract

A number of studies have suggested that lymphocytes producing polyreactive antibodies belong to the CD5+ B-cell subset. In this study we have examined CD5 at the cell surface and mRNA levels in EBV-driven cord blood and fetal liver clones previously characterized in terms of their antibody specificities. We show that EBV-immortalized cells can express surface CD5, and that some of the clones not expressing surface CD5 express it at the mRNA level. The complete absence of CD5 mRNA in some polyreactive clones is consistent with the proposition that the production of auto-antibodies and multispecific antibodies is not restricted to the CD5+ B-cell subset.

Item Type:Article
Research Areas:School of Science and Technology > Natural Sciences
ID Code:2528
Deposited On:12 Jan 2010 15:42
Last Modified:03 Feb 2014 07:26

Repository staff only: item control page

Full text downloads (NB count will be zero if no full text documents are attached to the record)

Downloads per month over the past year