Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

Green, J. and Ikram, Mohammed S. and Vyas, J. and Patel, N. and Proby, Charlotte M. and Ghali, Lucy and Leigh, Irene M. and O'Toole, Edel A. and Storey, Alan (2006) Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. British Journal of Cancer, 94 (10). pp. 1446-1451. ISSN 0007-0920

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Official URL: http://www.nature.com/bjc/journal/v94/n10/pdf/6603...

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Abstract

The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorly understood. We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell that mimic disease progression with the aim of identifying genes that may potentially contribute towards squamous cell carcinoma (SCC) progression in vivo, and in particular to identify markers that may serve as potential therapeutic targets for SCC treatment. Gene expression differences were corroborated by polymerase chain reaction and Western blotting. We identified Axl, a receptor tyrosine kinase with transforming potential that has also been shown to have a role in cell survival, adhesion and chemotaxis, was upregulated in vitro in SCC-derived cells compared to premalignant cells. Extending the investigation to tumour biopsies showed that the Axl protein was overexpressed in vivo in a series of SCCs.

Item Type:Article
Additional Information:

PubMed PMID: 16641895; PubMed Central PMCID: PMC2361292.

Research Areas:School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:9
ID Code:2526
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Deposited On:18 Jun 2009 13:41
Last Modified:03 Feb 2014 07:27

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