Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours
Green, J. and Ikram, Mohammed S. and Vyas, J. and Patel, N. and Proby, Charlotte M. and Ghali, Lucy and Leigh, Irene M. and O'Toole, Edel A. and Storey, Alan (2006) Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. British Journal of Cancer, 94 (10). pp. 1446-1451. ISSN 0007-0920
Full text is not in this repository.
Official URL: http://www.nature.com/bjc/journal/v94/n10/pdf/6603...
This item is available in the Library Catalogue
The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorly understood. We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell that mimic disease progression with the aim of identifying genes that may potentially contribute towards squamous cell carcinoma (SCC) progression in vivo, and in particular to identify markers that may serve as potential therapeutic targets for SCC treatment. Gene expression differences were corroborated by polymerase chain reaction and Western blotting. We identified Axl, a receptor tyrosine kinase with transforming potential that has also been shown to have a role in cell survival, adhesion and chemotaxis, was upregulated in vitro in SCC-derived cells compared to premalignant cells. Extending the investigation to tumour biopsies showed that the Axl protein was overexpressed in vivo in a series of SCCs.
PubMed PMID: 16641895; PubMed Central PMCID: PMC2361292.
|Research Areas:||A. Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group|
|Citations on ISI Web of Science:||9|
|Deposited On:||18 Jun 2009 13:41|
|Last Modified:||30 Jan 2015 16:55|
Repository staff only: item control page
Full text downloads (NB count will be zero if no full text documents are attached to the record)
Downloads per month over the past year