The immune system: first of two parts

Delves, Peter J. and Roitt, Ivan (2000) The immune system: first of two parts. New England Journal of Medicine, 343 (1). pp. 37-49. ISSN 0028-4793

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The immune system is an organization of cells and molecules with specialized roles in defending against infection. There are two fundamentally different types of responses to invading microbes. Innate (natural) responses occur to the same extent however many times the infectious agent is encountered, whereas acquired (adaptive) responses improve on repeated exposure to a given infection. The innate responses use phagocytic cells (neutrophils, monocytes, and macrophages), cells that release inflammatory mediators (basophils, mast cells, and eosinophils), and natural killer cells. The molecular components of innate responses include complement, acute-phase proteins, and cytokines such as the interferons.

Item Type:Article
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PubMed PMID: 10882768.

Research Areas:A. > School of Science and Technology > Natural Sciences
A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
Citations on ISI Web of Science:273
ID Code:2515
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Deposited On:18 Jun 2009 08:54
Last Modified:24 Mar 2015 14:08

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