Long non-coding RNA structure and function: Is there a link?

Zampetaki, Anna, Albrecht, Andreas A. and Steinhofel, Kathleen (2018) Long non-coding RNA structure and function: Is there a link? Frontiers in Physiology, 9 . ISSN 1664-042X (doi:10.3389/fphys.2018.01201)

[img]
Preview
PDF - Published version (with publisher's formatting)
Available under License Creative Commons Attribution.

Download (285kB) | Preview

Abstract

RNA has emerged as the prime target for diagnostics, therapeutics and the development of personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode proteins, display remarkable biochemical versatility. They can fold into complex structures and interact with proteins, DNA and other RNAs, modulating the activity, DNA targets or partners of multiprotein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of epigenetic control that is dysregulated
in disease. Intriguingly, for long non-coding RNAs (lncRNAs, >200 nucleotides length) structural conservation rather than nucleotide sequence conservation seems to be crucial for maintaining their function. LncRNAs tend to acquire complex secondary and
tertiary structures and their functions only impose very subtle sequence constraints. In the present review we will discuss the biochemical assays that can be employed to determine the lncRNA structural configurations. The implications and challenges of
linking function and lncRNA structure to design novel RNA therapeutic approaches will also be analyzed.

Item Type: Article
Additional Information: Article number = 1201 Corrigendum [03 September 2019] see also Data or Supplementary Material
Research Areas: A. > School of Science and Technology > Computer Science
Item ID: 24837
Useful Links:
Depositing User: Andreas Albrecht
Date Deposited: 29 Aug 2018 16:45
Last Modified: 20 Sep 2019 23:38
URI: https://eprints.mdx.ac.uk/id/eprint/24837

Actions (login required)

Edit Item Edit Item

Full text downloads (NB count will be zero if no full text documents are attached to the record)

Downloads per month over the past year