Comparison of methods for optimal choice of the regularization parameter for linear electrical impedance tomography of brain function
Abascal, Juan-Felipe and Arridge, Simon R. and Bayford, Richard and Holder, David S. (2008) Comparison of methods for optimal choice of the regularization parameter for linear electrical impedance tomography of brain function. Physiological measurement, 29 (11). pp. 1319-1334. ISSN 0967-3334
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Electrical impedance tomography has the potential to provide a portable non-invasive method for imaging brain function. Clinical data collection has largely been undertaken with time difference data and linear image reconstruction methods. The purpose of this work was to determine the best method for selecting the regularization parameter of the inverse procedure, using the specific application of evoked brain activity in neonatal babies as an exemplar. The solution error norm and image SNR for the L-curve (LC), discrepancy principle (DP), generalized cross validation (GCV) and unbiased predictive risk estimator (UPRE) selection methods were evaluated in simulated data using an anatomically accurate finite element method (FEM) of the neonatal head and impedance changes due to blood flow in the visual cortex recorded in vivo. For simulated data, LC, GCV and UPRE were equally best. In human data in four neonatal infants, no significant differences were found among selection methods. We recommend that GCV or LC be employed for reconstruction of human neonatal images, as UPRE requires an empirical estimate of the noise variance.
|Research Areas:||Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences|
Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences > Biophysics and Bioengineering group
|Citations on ISI Web of Science:||4|
|Deposited On:||21 May 2009 13:03|
|Last Modified:||09 Dec 2014 13:36|
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