The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells
Rooprai, Harcharan K. and Rucklidge, G. J. and Panou, C. and Pilkington, Geoffrey J. (2000) The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells. British journal of cancer, 82 (1). pp. 52-55. ISSN 0007-0920
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Official URL: http://www.nature.com/bjc/journal/v82/n1/abs/66908...
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Matrix metalloproteinases (MMPs) are a growing family of zinc-dependent endopeptidases that are capable of degrading various components of the extracellular matrix. These enzymes have been implicated in a variety of physiological and pathological conditions including embryogenesis and tumour invasion. The synthesis of many MMPs is thought to be regulated by growth factors, cytokines and hormones. In this study, we investigated the effects of five exogenous growth factors known to be expressed by gliomas [epidermal growth factor (EGF), basic growth factor (bFGF), transforming growth factor beta (TGF-1,2) and vascular endothelial growth factor (VEGF)] on MMP-2 and MMP-9 expression in an ependymoma, two grade III astrocytomas, a grade III oligoastrocytoma and a benign meningioma. Zymogram analysis revealed that the effects of the growth factors depended upon the cell lines used in the study. Growth factors generally up-regulated MMP-2 and MMP-9 expression in the gliomas but were least effective in the meningioma; the effect being most prominent with TGF-1 and TGF-2 in all the cell lines. It is hypothesized that paracrine growth factor interplay may be crucial in the regulation of MMP expression by glioma invasion of the normal brain. © 2000 Cancer Research Campaign.
|Research Areas:||School of Science and Technology > Natural Sciences|
|Citations on ISI Web of Science:||61|
|Deposited On:||21 May 2009 12:19|
|Last Modified:||04 Feb 2014 08:11|
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