The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome

Tozer, Amanda J. and Iles, Ray K. and Iammarrone, E. and Gillott, C. M. and Al-Shawaf, T. and Grudzinskas, J. G. (2004) The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome. Human Reproduction, 19 (3). pp. 522-528. ISSN 0268-1161

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Abstract

BACKGROUND: The aim of this study was to assess the effect of withholding gonadotrophins (coasting)
during controlled ovarian stimulation (COS) on individual follicle concentrations of follicular ¯uid vascular
endothelial growth factor (VEGF) in women at high risk of developing ovarian hyperstimulation syndrome
(OHSS). METHODS: Twenty-two women who had been coasted and 26 optimally responding women (control
group) undergoing COS for IVF were studied. At the time of oocyte retrieval, the follicular ¯uid from four to
six individual follicles of different sizes was collected for VEGF analysis. RESULTS: A total of 118 follicles
was analysed in the coasted group and 137 in the control group. A negative correlation was observed between
the follicle size and VEGF concentration (r = ±0.18, P = 0.03) in the control group, which was not seen in the
coasted group. Similarly, the correlation between oestradiol (E2) and VEGF (r = 0.4, P < 0.0001) observed in
the control group was not apparent in the coasted group. Signi®cantly lower concentrations of VEGF were seen in
the follicular ¯uid of the coasted patients. CONCLUSIONS: It is clear that there are differences in follicular ¯uid
VEGF concentrations between the two groups. It is possible that coasting alters the capacity of the granulosa cells to
produce VEGF and/or their response to hCG and in this way acts to reduce the severity and incidence of severe
OHSS.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
ISI Impact: 14
Item ID: 2374
Useful Links:
Depositing User: Repository team
Date Deposited: 20 May 2009 14:01
Last Modified: 13 Oct 2016 14:14
URI: http://eprints.mdx.ac.uk/id/eprint/2374

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