Investigating the longitudinal effect of ovariectomy on bone properties using a novel spatiotemporal approach

Lu, Yongtao and Liu, Yue and Wu, Chengwei and Li, Junyan (2018) Investigating the longitudinal effect of ovariectomy on bone properties using a novel spatiotemporal approach. Annals of Biomedical Engineering . ISSN 0090-6964 (Published online first)

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Abstract

Osteoporosis is the most common bone disease. However, the mechanism of osteoporosis-induced alterations in bone is still unclear. The aim of this study was to investigate the effects of osteoporosis on the structural, densitometric and mechanical properties of the whole tibia using in vivo μCT imaging, spatiotemporal analysis and finite element modeling. Twelve C57Bl/6 female mice were adopted. At 14 weeks of age, half of the mice were ovariectomized (OVX), and the other half were SHAM-operated. The whole right tibia was scanned using an in vivo μCT imaging system at 14, 16, 17, 18, 19, 20, 21 and 22 weeks. The image datasets were registered in order to precisely quantify the bone properties. The results showed that OVX led to a significant increase in the endosteal area across the whole tibia 4 weeks after OVX intervention but did not have a significant influence on the periosteal area. Additionally, the bone volume and mineral content significantly decreased only in the proximal regions, but these decreases did not have a significant influence on the stiffness and failure load of the tibia. This study demonstrated the application of a novel spatiotemporal approach in the comprehensive analysis of bone adaptations in the spatiotemporal space.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences > Biophysics and Bioengineering group
Item ID: 23652
Notes on copyright: This is a post-peer-review, pre-copyedit version of an article published in Annals of Biomedical Engineering. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10439-018-1994-x
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Depositing User: Junyan Li
Date Deposited: 26 Feb 2018 13:36
Last Modified: 22 Feb 2019 04:04
URI: http://eprints.mdx.ac.uk/id/eprint/23652

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