pH regulation of penicillin production in Aspergillus nidulans

Shah, Ajit J. and Tilburn, Joan and Adlard, Maxwell W. and Arst, Herbert. N. (1991) pH regulation of penicillin production in Aspergillus nidulans. FEMS microbiology letters, 77 (2-3). pp. 209-212. ISSN 0378-1097

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Abstract

As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pacC which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the palA, palB, palC, palE or palF genes which mimic the effects of growth at acid pH.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
Item ID: 23482
Useful Links:
Depositing User: Ajit Shah
Date Deposited: 02 Feb 2018 11:37
Last Modified: 02 Feb 2018 11:37
URI: http://eprints.mdx.ac.uk/id/eprint/23482

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