Inheritance of oscillation in chemical reaction networks

Banaji, Murad (2018) Inheritance of oscillation in chemical reaction networks. Applied Mathematics and Computation, 325 . pp. 191-209. ISSN 0096-3003 (doi:10.1016/j.amc.2017.12.012)

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Some results are presented on how oscillation is inherited by chemical reaction networks (CRNs) when they are built in natural ways from smaller oscillatory networks. The main results describe four important ways in which a CRN can be enlarged while preserving its capacity for oscillation. The results are for general CRNs, not necessarily fully open, but lead to an important corollary for fully open networks: if a fully open CRN R with mass action kinetics admits a nondegenerate (resp., linearly stable) periodic orbit, then so do all such CRNs which include R as an induced subnetwork. This claim holds for other classes of kinetics, but fails, in general, for CRNs which are not fully open. Where analogous results for multistationarity can be proved using the implicit function theorem alone, the results here call on regular and singular perturbation theory. Equipped with these results and with the help of some analysis and numerical simulation, lower bounds are put on the proportion of small fully open CRNs capable of stable oscillation under various assumptions on the kinetics. This exploration suggests that small oscillatory motifs are an important source of oscillation in CRNs.

Item Type: Article
Research Areas: A. > School of Science and Technology > Design Engineering and Mathematics
Item ID: 23316
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Depositing User: Murad Banaji
Date Deposited: 15 Jan 2018 15:18
Last Modified: 05 Apr 2019 11:12

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