A systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies

Purewal, Satvinder and Chapman, Sarah and van den Akker, Olga (2017) A systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies. Journal of Psychosomatic Obstetrics & Gynecology . ISSN 0167-482X (Published online first)

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Abstract

Lifestyle (smoking, drinking alcohol) and body mass index (BMI) predictors of successful outcomes in assisted reproductive technology (ART) treatments were examined in this meta-analysis.

Method: A bibliographic search was undertaken using 6 databases. The review was informed by PRISMA/MOOSE guidelines. Meta-analytic data were analysed using random effects models.

Results: We included 77 studies examining effects of BMI, smoking and drinking alcohol. Patients with a BMI <=24.9 were significantly more likely to achieve LB/pregnancy than with BMI >=25 OR=1.219 (95% CI:1.128-1.319, z=4.971, p<001; I2=53.779%, p=0.001). Non-smokers were significantly more likely to achieve a LB or pregnancy than smokers OR=1.457 (95% CI:1.228-1.727, z=4.324, p< 0.001; I2=51.883; p=0.001). Meta-regression revealed the number of embryos transferred significantly moderated the effects of smoking on ART outcomes, and there was a trend indicating primary infertility and high BMI were also significant moderators. The evidence for drinking alcohol was inconclusive due to the small number of studies.

Conclusion: This meta-analysis confirms that ART treatment success can be predicted with lifestyle factors. Further, non-smokers’ relative odds of pregnancy/live birth increase as more embryos were transferred but there was a trend that the odds of pregnancy/live birth decrease with primary infertility and high BMI.

Item Type: Article
Research Areas: A. > School of Science and Technology > Psychology > Applied Health Psychology group
Item ID: 23078
Notes on copyright: This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Psychosomatic Obstetrics & Gynecology on 27/11/2017, available online: http://www.tandfonline.com/10.1080/0167482X.2017.1403418
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Depositing User: Olga Van Den akker
Date Deposited: 05 Dec 2017 10:43
Last Modified: 01 Dec 2018 08:47
URI: http://eprints.mdx.ac.uk/id/eprint/23078

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