Orexin A activates locus coeruleus cell firing and increases arousal in the rat

Hagan, Jim J. and Leslie, Ron A. and Patel, Sara and Evans, Martyn L. and Wattman, Trevor A. and Holmes, Steve and Benham, Christopher D. and Routledge, Carol and Hemmati, Panida and Munton, Richard P. and Ashmeade, Tracey E. and Shah, Ajit J. and Hatcher, Johnathan P. and Jones, Declan N. C. and Smith, Martin I. and Piper, David C. and Hunter, Jackie A. and Porter, Rod A. and Upton, Neil (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proceedings of the National Academy of Sciences, 96 (19). pp. 10911-10916. ISSN 1091-6490

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Abstract

The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 22829
Depositing User: Ajit Shah
Date Deposited: 03 Nov 2017 12:03
Last Modified: 03 Nov 2017 12:06
URI: http://eprints.mdx.ac.uk/id/eprint/22829

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