Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries

Tolson, David and Organ, Andy J. and Shah, Ajit J. (2001) Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries. Rapid Communications in Mass Spectrometry, 15 (14). pp. 1244-1249.

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Abstract

Parallel liquid chromatography/mass spectrometer (LC/MS) systems such as the Micromass MUX™ have been commercially available for several years. Until recently, the LC pumping systems available have been a serious limitation to the more widespread adoption of such systems, particularly in good laboratory practice (GLP) environments. In this work, we compare the performance of the Jasco PAR-1500 pumping system, which delivers an equal gradient flow to eight individual flow channels, to that of a conventional system, where the flow is split post pump. Both systems were coupled to a Micromass LCT™ liquid chromatography/electrospray ionisation time-of-flight (LC/ESI-TOF) mass spectrometer equipped with a parallel MUX™ inlet system, used for the analysis of combinatorial libraries. In addition to flow stability, the Jasco system has resulted in a dramatic improvement in chromatographic performance. Copyright © 2001 John Wiley & Sons, Ltd.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 22790
Depositing User: Ajit Shah
Date Deposited: 01 Nov 2017 10:14
Last Modified: 01 Nov 2017 10:14
URI: http://eprints.mdx.ac.uk/id/eprint/22790

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