The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines

Senior, John, Shah, Ajit J., Monteux, Cecile and de Biasi, Vern (2001) The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines. Journal of Pharmaceutical and Biomedical Analysis, 24 (5-6). pp. 843-848. ISSN 0731-7085 (doi:10.1016/S0731-7085(00)00551-3)

Full text is not in this repository.

Abstract

The use of Interdigitated Array (IDA) Microelectrodes for detection of low levels of biogenic amines has been demonstrated in stationary solutions and flow systems [M. Morita, et al., Electrochemica Acta 42 (20--21) (1997) 3177--3183]. This technique is highly sensitive. We have evaluated this technology as applied to High Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC) for analysis of microdialysate and tissue samples. With this new technology we demonstrated a x 10 fold increase in sensitivity in comparison to our existing technology. We are now able to detect dopamine at a level of 53 x 10(-18) moles on column and serotonin at 26 x 10(-18) moles on column. This technology now permits analysis of biogenic amines in samples from brain areas not previously amenable to this type of experiment.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 22789
Useful Links:
Depositing User: Ajit Shah
Date Deposited: 01 Nov 2017 10:13
Last Modified: 11 Jun 2019 11:33
URI: https://eprints.mdx.ac.uk/id/eprint/22789

Actions (login required)

Edit Item Edit Item