The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines

Senior, John, Shah, Ajit J. ORCID: https://orcid.org/0000-0002-2350-6384, Monteux, Cecile and de Biasi, Vern (2001) The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines. Journal of Pharmaceutical and Biomedical Analysis, 24 (5-6) . pp. 843-848. ISSN 0731-7085 (doi:10.1016/S0731-7085(00)00551-3)

Abstract

The use of Interdigitated Array (IDA) Microelectrodes for detection of low levels of biogenic amines has been demonstrated in stationary solutions and flow systems [M. Morita, et al., Electrochemica Acta 42 (20--21) (1997) 3177--3183]. This technique is highly sensitive. We have evaluated this technology as applied to High Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC) for analysis of microdialysate and tissue samples. With this new technology we demonstrated a x 10 fold increase in sensitivity in comparison to our existing technology. We are now able to detect dopamine at a level of 53 x 10(-18) moles on column and serotonin at 26 x 10(-18) moles on column. This technology now permits analysis of biogenic amines in samples from brain areas not previously amenable to this type of experiment.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 22789
Useful Links:
Depositing User: Ajit Shah
Date Deposited: 01 Nov 2017 10:13
Last Modified: 28 Nov 2019 14:02
URI: https://eprints.mdx.ac.uk/id/eprint/22789

Actions (login required)

Edit Item Edit Item