Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection?

Iles, Ray K. and Butler, Stephen A. (2003) Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? Clinical Cancer Research, 9 (13). pp. 4666-4673. ISSN 1078-0432

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Official URL: http://clincancerres.aacrjournals.org/cgi/content/...

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Abstract

Since it was first claimed in 1995 that human chorionic gonadotropin (hCG) inhibits HIV-associated Kaposi’s sarcoma (KS), focus has been lost on establishing a credible hypothesis to explain a novel action ascribed to hCG, which is, after all, a pregnancy hormone. After 7 years, no real progress has been made, and there remains no consensus as to which component of hCG preparations is responsible for inducing apoptosis of HIV-associated KS. It would certainly seem apparent that many basic experiments on hCG species have been overlooked in the studies that have been published. Furthermore, the much wider literature concerning the association of hCG with promoting oncogenesis has been ignored. This review puts into context the numerous studies on hCG, HIV-associated KS, and oncogenesis.

Item Type:Article
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With permission from Clinical Cancer Research/American Association for Cancer Research, 2008.

Research Areas:School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:24
ID Code:226
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Deposited On:29 Oct 2008 17:42
Last Modified:28 Mar 2014 06:22

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