Can mesenchymal stem cells survive under normal impaction force in revision total hip replacements?

Korda, Michelle, Blunn, Gordon, Phipps, Kirsty, Rust, Philippa, Di Silvio, Lucy, Coathup, Melanie, Goodship, Allen and Hua, Jia (2006) Can mesenchymal stem cells survive under normal impaction force in revision total hip replacements? Tissue engineering, 12 (3). pp. 625-630. ISSN 1076-3279

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Abstract

Impaction allograft as a scaffold for bone-forming cells is a tissue-engineering approach for filling bone defects that are commonly encountered during revision total joint replacement (THR). The purpose of this in vitro study is to assess the viability of mesenchymal stem cells (MSC) grown on allograft following impaction using forces similar to those measured during revision total hip replacements. Impaction forces of 0, 3, 6, and 9 kN were used representing normal and high impact. The results showed that the viability in the 3 and 6 kN groups was not significantly reduced compared with that of the 0 kN group, while the survival of the MSCs was significantly reduced after 9 kN impaction force. This study suggests that the addition of MSCs to the allograft scaffold will survive normal impaction force in revision THR.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 16571
Useful Links:
Depositing User: Jia Hua
Date Deposited: 29 May 2015 13:54
Last Modified: 30 May 2019 18:28
URI: https://eprints.mdx.ac.uk/id/eprint/16571

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