Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity

Loizidou, Erika and Zeinalipour-Yazdi, Constantinos D. (2014) Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity. Chemical Biology and Drug Design, 84 (1) . pp. 99-107. ISSN 1747-0277 (doi:10.1111/cbdd.12298)

Abstract

A computational procedure was developed to study the subunit-specific interactions of the proteasome inhibitors argyrin A and F, with the aim of indentifying the determinants of subunit selectivity. Three-dimensional models of humanized proteasome active sites β1, β2 and β5 were developed and subsequently used in molecular docking simulations with the argyrin analogues. The subunit selectivity exhibited by each analogue could be explained based on the site-specific interactions and a probability-based specificity parameter derived in this study. A rational approach that involved maximizing site-specific interactions was followed to guide the design of new argyrin analogues as specific inhibitors of the caspase-like (β1 site) activity.

Item Type: Article
Additional Information: Article first published online: 12 MAY 2014
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 14372
Depositing User: Erika Loizidou
Date Deposited: 06 Mar 2015 13:20
Last Modified: 13 Oct 2016 14:32
URI: https://eprints.mdx.ac.uk/id/eprint/14372

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