Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

Bianchi, Massimiliano, Fone, Kevin C. F., Shah, Ajit J., Atkins, Alan R., Dawson, Lee A., Heidbreder, Christian A., Hagan, Jim J. and Marsden, Charles A. (2009) Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats. European Neuropsychopharmacology, 19 (11). pp. 778-790. ISSN 0924-977X

Full text is not in this repository.

Abstract

Social isolation from weaning in rats produces behavioural and hippocampal structural changes at adulthood. Here, rats were group or isolation reared for eight-weeks. Following the initial four-week period of rearing, fluoxetine (10 mg/kg i.p.) was administered for 28 days. Changes in recognition memory, hippocampal monoamines, and cytoskeletal microtubules were investigated. Isolation-rearing for four- or eight-weeks produced recognition memory deficits that were not reversed by fluoxetine. Eight-weeks of isolation decreased α-tubulin acetylation (Acet-Tub) and the tyrosinated/detyrosinated α-tubulin ratio (Tyr/Glu-Tub), suggesting major alterations in microtubule dynamics and neuronal plasticity. In grouped rats, fluoxetine decreased Acet-Tub without changes in Tyr/Glu-Tub. In isolates, fluoxetine did not affect Acet-Tub but increased Tyr/Glu-Tub. Finally, fluoxetine altered serotonin metabolism in grouped, but not in isolated animals. Therefore, isolation-rearing changes the hippocampal responses of the serotonergic and microtubular system to fluoxetine. These findings show that early-life experience induces behavioural changes paralleled by alterations in cytoskeletal and neurochemical functions.

Item Type: Article
Keywords (uncontrolled): Isolation rearing; Fluoxetine; Microtubules; Alpha-tubulin; Neuronal plasticity; Depression
Research Areas: A. > School of Science and Technology > Natural Sciences
A. > School of Science and Technology > Natural Sciences > Reproductive Biology group
A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
Item ID: 12452
Useful Links:
Depositing User: Users 3197 not found.
Date Deposited: 06 Nov 2013 15:33
Last Modified: 13 Oct 2016 14:29
URI: https://eprints.mdx.ac.uk/id/eprint/12452

Actions (login required)

Edit Item Edit Item