Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium

Nouwen, Arie ORCID: https://orcid.org/0000-0002-0609-4082, Nefs, Giesje, Caramlau, Isabela, Connock, Martin, Winkley, Kirstly, Lloyd, Cathy E., Peyrot, Mark and Pouwer, François (2011) Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium. Diabetes Care, 34 (3). pp. 752-762. ISSN 0149-5992 (doi:10.2337/dc10-1414)

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Abstract

OBJECTIVE: Meta-analyses have shown that the risk for depression is elevated in type 2 diabetes. Whether this risk in individuals with impaired glucose metabolism (IGM) or undiagnosed diabetes (UDD) is elevated relative to normal glucose metabolism (NGM) or decreased relative to previously diagnosed type 2 diabetes (PDD) has not been the subject of a systematic review/meta-analysis. This study examined the prevalence of depression in IGM and UDD subjects relative to each other and to NGM and PDD subjects by reviewing the literature and conducting a meta-analysis of studies on this topic.

RESEARCH DESIGN AND METHODS: EMBASE and MEDLINE databases were searched for articles published up to May 2010. All studies that compared the prevalence of depression in subjects with IGM and UDD were included. Odds ratios (ORs) were calculated using fixed and random-effects models.

RESULTS: The meta-analysis showed that the risk for depression was not increased in IGM versus NGM subjects (OR 0.96, 95% CI 0.85–1.08). Risk for depression did not differ between individuals with UDD and individuals with either NGM (OR 0.94, 95% CI 0.71–1.25) or IGM (OR 1.16, 95% CI 0.88–1.54). Finally, individuals with IGM or UDD both had a significantly lower risk of depression than individuals with PDD (OR 0.59, 95% CI 0.48–0.73, and OR 0.57, 95% CI 0.45–0.74, respectively).

CONCLUSIONS: Results of this meta-analysis show that the risk of depression is similar for NGM, IGM, and UDD subjects. PDD subjects have an increased risk of depression relative to IGM and UDD subjects.

Item Type: Article
Additional Information: This article contains supplementary data online at http://care.diabetesjournals.org/content/suppl/2011/02/24/34.3.752.DCSupplementary_Data/DC101414SupplementaryData.pdf
Research Areas: A. > School of Science and Technology > Psychology
A. > School of Science and Technology > Psychology > Applied Health Psychology group
Item ID: 12198
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Depositing User: Users 3197 not found.
Date Deposited: 16 Oct 2013 10:47
Last Modified: 11 Oct 2019 13:30
URI: https://eprints.mdx.ac.uk/id/eprint/12198

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