Elevated cortical glutamate in young people at increased familial risk of depression

Taylor, Matthew J., Mannie, Zola N., Norbury, Ray, Near, Jamie and Cowen, Philip J. (2011) Elevated cortical glutamate in young people at increased familial risk of depression. The International Journal of Neuropsychopharmacology, 14 (02). pp. 255-259. ISSN 1461-1457 (doi:10.1017/S1461145710001094)

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Abstract

Using proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an after-effect of episodes of illness or its treatment. We sought to examine this question by examining a group of high-risk, never-depressed, individuals. We used MRS to measure GABA and glutamate in parieto-occipital cortex in young people (ages 16–21 yr) with a family history of parental depression (n=24) but no personal history of illness and a control group without a history of depression in any first-degree relative (n=28). Participants with a parental history of depression had significantly higher levels of glutamate than controls in parieto-occipital cortex (F1,47=5.5, p=0.02). These findings suggest that abnormalities in glutamate neurotransmission may reflect a trait marker of vulnerability to depression.

Item Type: Article
Research Areas: A. > School of Science and Technology > Psychology
A. > School of Science and Technology > Psychology > Applied Health Psychology group
Item ID: 12185
Depositing User: Users 3197 not found.
Date Deposited: 15 Oct 2013 12:34
Last Modified: 13 Oct 2016 14:29
URI: https://eprints.mdx.ac.uk/id/eprint/12185

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