Switching on kinases: oncogenic activation of BRAF and the PDGFR family

Dibb, Nick J., Dilworth, Stephen M. and Mol, Clifford D. (2004) Switching on kinases: oncogenic activation of BRAF and the PDGFR family. Nature Reviews Cancer, 4 (9). pp. 718-727. ISSN 1474-175X

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Abstract

The cytoplasmic serine/threonine kinase BRAF and receptor tyrosine kinases of the platelet-derived growth factor receptor (PDGFR) family are frequently activated in cancer by mutations of an equivalent amino acid. Structural studies have provided important insights into why these very different kinases share similar oncogenic hot spots and why the PDGFR juxtamembrane region is also a frequent oncogenic target. This research has implications for other kinases that are mutated in human tumours and for the treatment of cancer using kinase inhibitors.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences > Molecular Biology group
A. > School of Science and Technology > Natural Sciences
Item ID: 10103
Useful Links:
Depositing User: Professor Stephen M. Dilworth
Date Deposited: 19 Feb 2013 08:51
Last Modified: 13 Oct 2016 14:26
URI: https://eprints.mdx.ac.uk/id/eprint/10103

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